Gut-Immune Axis: How the Microbiome Shapes the Systemic Immune Response in Health and Disease
It is estimated that over 80% of our immune tissue is found in the gastrointestinal tract. This same space is occupied by over 40 trillion microorganisms, practically from the day we are born. Overwhelming scientific evidence illustrates the critical role these microbes play in both the function and dysfunction of the immune system. Microbiome-initiated immunological dysregulation is a primary cause of many non-infectious diseases such as autoimmunity, allergies, asthma, and cancer.
This talk will discuss the role of the microbiome in the development and function of the adaptive and innate immune system and their ability to respond to challenge. The talk will also focus on the key molecular pathways that mediate the host-microbiome interactions that regulate daily and homeostatic immune function. The talk will cover the types of microbiome disruptions that lead to immunological dysregulation and an inability to mount an effective response. We will also discuss the role of the microbiome in the recovery from infection and the resulting tissue damage. Finally, we will discuss some potential microbiome-targeted, therapeutic approaches to improve immune function and reduce the risk for dysregulation.
Kiran Krishnan is a Research Microbiologist and has been involved in the dietary supplement and nutrition market for the past 20 years. He comes from a strict research background having spent several years with hands-on R&D in the fields of molecular medicine and microbiology at the University of Iowa. He left University research to take several leadership positions in global companies in Business Development and Product Development. Most recently, Kiran is a Co-Founder and the Chief Scientific Officer at Microbiome Labs, a leader in microbiome and probiotic research. He is a frequent lecturer on the human microbiome at medical and nutrition conferences. He is an expert guest on national radio and satellite radio and has been a guest speaker on several health summits as a microbiome expert. He is currently involved in over 18 novel human clinical trials on probiotics and the human microbiome. Kiran is also on the Scientific Advisory Board for 7 other companies in the industry. Kiran has published clinical trials in peer-reviewed, scientific journals and has several global patents in his name.
